MIT scientists develop a new way to grow artificial blood vessels
Artificial tissues can mimic muscle, liver, kidney and skin, but they still face a basic survival problem: cells need blood vessels. Without a dense vascular network, oxygen and nutrients cannot reach deep into engineered tissue, and waste cannot escape. MIT engineers have now shown that mechanical stretching can help solve that problem. By repeatedly pulling on a lab-grown vessel, they increased the growth of new capillary-like sprouts and guided the direction those sprouts followed. The work, reported in the Proceedings of the National Academy of Sciences, introduces a vessel-on-a-chip platform that uses magnets to apply controlled strain inside a three-dimensional tissue model. The system lets researchers adjust how strongly, how often and in which direction a vessel is stretched. “Healthy tissues depend on organized blood vessel networks, but state-of-the-art protocols don’t enable fabricating such networks within engineered tissues,” said Ritu Raman, an associate professor of mechanical engineering at MIT and the study’s co-lead author. “The ability to program blood vessel growth with physical cues may enable reproducible and scalable fabrication of engineered tissues that can …









