A new analysis of global pharmacovigilance data indicates that while reports of psychiatric distress are common among users of classic psychedelics and MDMA, severe physical health complications appear to be relatively rare in real-world settings. The study suggests that the high rates of reported substance abuse associated with these drugs may be heavily influenced by the simultaneous consumption of other intoxicants rather than the psychedelics alone. These findings were published in Psychiatry Research. The consumption of psychedelic substances has increased significantly in recent years. This rise has occurred in both clinical settings, where researchers are testing these compounds for therapeutic potential, and in unregulated recreational environments. National surveys in the United States have documented a steady growth in the use of LSD and other hallucinogens among adults over the last two decades. While clinical trials generally indicate that these substances have a favorable safety profile, such studies are conducted under strictly controlled conditions with carefully screened participants. Clinical trials often exclude individuals with complex medical or psychiatric histories to ensure safety and data clarity. This …