Autism genetics linked to reduced brain cell fiber density
Individuals who carry common genetic variants associated with autism tend to have lower density in the brain’s microscopic wiring, regardless of whether they actually have an autism diagnosis. The research reveals a shared genetic architecture between the likelihood of autism and the microscopic development of the brain. The study was published in the journal Molecular Psychiatry. Autism is a condition influenced by a vast pool of genetic variations spread across human DNA. Each minor genetic difference has only a tiny effect on its own, but combined, they shape a person’s underlying likelihood of developing the condition. This type of genetic architecture is called polygenic inheritance. Researchers have documented structural brain differences in autistic individuals for many years. However, much less is known about how the multitude of genes linked to autism might affect the physical structure of the brain in the broader public. Genetic traits often influence physical characteristics across an entire population on a sliding scale. To answer these questions, scientists look for subtle patterns in large databases of health records. Yuanjun Gu and …





