Removing ‘invisibility cloaks’ and safely skipping chemo: new weapons in war on cancer shared at US conference | Cancer research
1. Smart drugs can help patients kill off their own tumours Immunotherapy drugs, which harness the body’s immune system to attack tumours, have revolutionised cancer treatment over the last decade. But they don’t work in every patient. Their effectiveness can falter or fail when cancer cells hide. Now researchers have developed a smart drug that stops cancer cells hiding. The experimental tablet, GRWD5769, can help shrink tumours by at least 30% in six of the world’s most common forms of the disease, delegates in Chicago were told. All of the patients in a trial spanning the UK, France, Spain and Australia had previously failed to respond to treatment. Most had no options left when they joined the study. Crucially, immunotherapy had not worked or had stopped working. The smart drug was able to remove “invisibility cloaks” from tumour cells, exposing them to the parts of the immune system that attack infections and diseases. This enabled an immunotherapy drug, cemiplimab, to detect and then destroy the cancer. Researchers led by the Christie NHS foundation trust in …









