No proteins required: Newly discovered enzyme can hunt and mend broken RNA
The oldest question in biology has a trap built into it. DNA holds the instructions for making proteins. Proteins are needed to copy, repair, and read DNA. Each depends on the other, which raises an obvious problem: how did either one get started? The most popular answer is that neither came first. Before both, there was RNA, a single molecule able to do two jobs at once, storing genetic information like DNA and speeding up chemical reactions like a protein. That idea, the RNA World hypothesis, has one persistent weakness. For an RNA-based lifeform to survive, it needed a way to fix its own genetic material when it broke, and no one had shown that RNA could do that repair job by itself. A team led by biochemist Saurja DasGupta at the University of Notre Dame now has, published in Nature Communications. And the way they found it was almost entirely by accident. Saurja DasGupta, Assistant Professor of Chemistry & Biochemistry. (CREDIT: Matt Cashore/University of Notre Dame) An Experiment That Went Sideways DasGupta’s lab was …








