All posts tagged: tissue engineering

New holographic 3D printer could revolutionize tissue engineering

New holographic 3D printer could revolutionize tissue engineering

Volumetric 3D printing can create full objects in seconds, but wasted light has held it back. An EPFL team now redirects laser energy far more efficiently, producing larger, cleaner, cell-filled structures with gentler power, and pushing bioprinting closer to medical reality. A team of researchers at the École Polytechnique Fédérale de Lausanne, known as EPFL, has developed a major upgrade to a futuristic form of 3D printing that creates entire objects almost instantly using light. Their new method dramatically improves efficiency and precision, bringing scientists closer to printing large, tissue-like structures that could someday help repair the human body. The breakthrough centers on a technology called tomographic volumetric additive manufacturing, or TVAM. Unlike traditional 3D printers that build objects layer by layer, TVAM creates complete three-dimensional structures inside a rotating vial of liquid resin. Laser light hardens selected regions of the liquid until a finished object suddenly appears. In earlier versions of the technology, much of the laser’s energy was wasted. The EPFL team found a way to preserve far more of that power by …

New hydrogel prints bone-like implants at record speed

New hydrogel prints bone-like implants at record speed

A cube of healthy bone is anything but solid. Inside it, countless tiny channels carry fluid and help cells move, feed, and rebuild. Xiao-Hua Qin, a professor of biomaterials engineering at ETH Zurich, likes a striking comparison: “A piece of bone the size of a dice contains 74 kilometers of tunnels.” The Gotthard Base Tunnel, the world’s longest railway tunnel, runs 54 kilometers. That hidden architecture is one reason broken bones usually heal, and one reason severe breaks can become a surgical puzzle. When a fracture is too extensive, or when surgeons remove a bone tumor, they often rely on implants that help the body knit the gap back together. Many of today’s options involve autografts, pieces of a patient’s own bone, or metal and ceramic parts. Autografts can require a second surgery to harvest tissue. Metal implants, meanwhile, can be too rigid and may loosen over time, which can compromise stability. Qin and colleagues are now pushing a different idea: an implant material that starts soft, like the body’s own first step in repair, …

MIT engineers built injectable ‘satellite livers’ as an alternative to liver transplants

MIT engineers built injectable ‘satellite livers’ as an alternative to liver transplants

More than 10,000 Americans are waiting for a liver transplant. Many more never make the list, because they are too sick to handle a major surgery. That gap is why an idea that sounds a little strange at first keeps coming up in liver research: What if you could add liver function without replacing the liver? MIT engineers are pushing that concept with what they call “satellite livers,” small pockets of liver tissue that can be injected and left to do some of the liver’s work while the damaged organ stays in place. “We think of these as satellite livers. If we could deliver these cells into the body, while leaving the sick organ in place, that would provide booster function,” says Sangeeta Bhatia, the John and Dorothy Wilson Professor of Health Sciences and Technology and of Electrical Engineering and Computer Science at MIT. She is also a member of MIT’s Koch Institute for Integrative Cancer Research and the Institute for Medical Engineering and Science (IMES). In a mouse study, Bhatia’s team showed that injected …