Following a three-decade career at the helm of some of Silicon Valley’s most powerful companies—cofounding LinkedIn and sitting on the boards of PayPal and OpenAI—Reid Hoffman recently turned his attention to health care. Hoffman’s startup, Manas AI, is building an AI engine that aims to fast-track the traditionally slow process of drug discovery for various cancers. Inspired by a dinner with renowned cancer physician Siddhartha Mukherjee, the company’s cofounder and CEO, its mission statement is to “shift drug discovery from a decade-long process to one that takes a few years.” But Hoffman’s enthusiasm for generative AI, in particular, stretches far beyond novel drug targets and small molecules. He believes that frontier models—the most advanced, large-scale AI models currently available from companies like OpenAI and Anthropic—should be a cornerstone of health care itself. “If as a doctor, you’re not using one or more frontier models as a second opinion, my belief is you’re bordering on committing malpractice,” Hoffman said, speaking at WIRED Health in London on April 16. “These AI systems, even though many of them …