Parkinson’s drug helps restore pleasure and motivation in depression patients
In a randomized placebo-controlled trial, pramipexole significantly improved anhedonia in people with mood disorders who continued their existing antidepressant or mood-stabilizing treatment. The Parkinson’s drug was also associated with greater light physical activity and relative preservation of reward-related activity in the ventral striatum, offering evidence that the treatment engaged brain systems linked to motivation. The findings are promising but preliminary. The trial was conducted at a single center with 85 randomized participants, and larger studies are needed before pramipexole could become a routine treatment for anhedonia. A loss of joy can quietly reshape a person’s life. Activities that once brought meaning begin to feel distant or empty. This experience, known as anhedonia, remains one of the most difficult symptoms of depression to treat. A new study led by researchers at Lund University, in collaboration with psychiatric services in Region Skåne, offers a possible new path forward. The research suggests that a drug long used for Parkinson’s disease may help restore motivation and pleasure in people with depression. The medication, pramipexole, is not new. Doctors have …







