All posts tagged: sexually transmitted diseases

Scientists discover how some people control HIV without daily medication

Scientists discover how some people control HIV without daily medication

For decades, HIV treatment has depended on one hard truth: once medication stops, the virus usually comes roaring back. Modern antiretroviral drugs can suppress HIV so effectively that many people live long, healthy lives. They can work, raise families and prevent transmission. Yet the virus never fully disappears. It hides deep inside immune cells, waiting for another chance to spread. Now, researchers from Aarhus University Hospital and international collaborators have uncovered new clues about how a small group of people managed to keep HIV under control for years without daily medication. Their findings suggest the immune system may be capable of doing what medicine alone has struggled to achieve. The key appears to lie in a powerful partnership between antibodies and T cells. Summary of assays performed. (CREDIT: Nature Immunology) “We can see that two branches of the immune system work together to control the virus. One targets one aspect of the virus, the other targets another. Together, they are effective enough to prevent the virus from escaping,” said Professor Ole Schmeltz Søgaard of Aarhus …

New discovery helps explain why HIV can return so quickly

New discovery helps explain why HIV can return so quickly

A long-standing belief about HIV has quietly shaped how scientists think about the virus. For decades, researchers described the virus as hiding in a “latent reservoir,” a group of infected cells that stay silent during treatment. New research now challenges that idea, revealing a more active and complex picture inside the body. For people living with human immunodeficiency virus, antiretroviral therapy has transformed the disease. These drugs stop the virus from making new copies, which prevents illness and reduces transmission. Yet even with treatment, HIV does not fully disappear. “But notion that the entirety of the HIV reservoir is latent is actually a misleading description, because some reservoir cells can still be quite active,” said Nadia Roan, PhD, senior investigator at Gladstone Institutes. “Even though antiretroviral therapy keeps full-fledged HIV virus from being made, some of the infected cells continue spitting out viral products.” That activity, though subtle, can have real consequences. Viral fragments remain in the body, which can drive chronic inflammation. Over time, that inflammation can contribute to organ damage and increase the …

FDA-approved cancer drug may treat drug-resistant herpes

FDA-approved cancer drug may treat drug-resistant herpes

A drug long used to fight cancer may soon take on a very different role. Researchers at the University of Illinois Chicago have found that doxorubicin, an FDA-approved chemotherapy medicine, can block drug-resistant herpes infections in early studies. The discovery offers hope for patients who face limited treatment options when standard antivirals stop working. The research centers on herpes simplex virus type 1, known as HSV-1. This virus infects billions of people worldwide and stays in the body for life. For many, it causes cold sores. For others, especially those with weakened immune systems, it can lead to serious complications, including brain inflammation and organ failure. “This opens up an unexpected, potentially fast-moving path toward treating drug-resistant herpes infections,” said Deepak Shukla, a virologist in the College of Medicine at UIC. “HSV-1 infections have serious, sometimes life-threatening consequences, and this drug may help save lives.” A Growing Problem With Few Solutions HSV-1 has challenged doctors for decades. Standard antiviral drugs such as acyclovir can control outbreaks by stopping the virus from copying itself. These medicines …