Blood cells originated from single-celled ancestors 700 million years ago
Blood cells carry a deep evolutionary history. A new analysis suggests their earliest ancestors were macrophage-like cells inherited from single-celled life. By tracing those lineages back 700 million years, the work opens a new window into immunity’s ancient roots. Blood does more than move oxygen and fight infection. It also carries a record of where animals came from. A new evolutionary analysis suggests that the roots of blood cells stretch back roughly 700 million years. That period was when the first multicellular animals were beginning to emerge. In that picture, some cells now circulating through vertebrate bodies may trace their origins to genetic programs inherited from single-celled ancestors. The work, led by researchers at Kyoto University, set out to answer a basic but stubborn question. Scientists know a great deal about what human and mouse blood cells do. However, they know much less about when those cells first appeared and how they split into the many lineages seen today. To tackle that, the team developed a new method for comparing gene expression profiles across cell …

