Pep Guardiola’s side went top of the Premier League on Wednesday night after beating Burnley at Turf Moor, and can keep their hopes of a domestic double alive against Tonda Eckert’s Saints.
The south coast side stunned Arsenal in the previous round to reach this stage of the tournament, winning 2-1 thanks to goals from Ross Stewart and Shea Charles.
They last reached an FA Cup final in 2003 and will require another huge upset if they are to end that 23-year wait here.
Southampton do come into the match on form, though, with a midweek draw with Bristol City ending an eight-match winning streak.
Date, kick-off time and venue
Man City vs Southampton is scheduled for a 5.15pm BST kick-off on Saturday, April 25, 2026.
The match will take place at Wembley Stadium.
Where to watch Man City vs Southampton
TV channel: In the UK, the game will be televised live on BBC One and TNT Sports.
Coverage will start at 4.45pm on BBC One and 4pm on TNT Sports 1.
Live stream: TNT Sports subscribers can also catch the contest live online via the HBO Max app and website. Those with a TV license can also follow the action on BBC iPlayer.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, complete with expert insight and analysis.
Man City vs Southampton team news
Man City may be without Ballon d’Or-winning midfielder Rodri after he was injured in the defeat of Arsenal last week, but Guardiola seems optimistic he can feature.
Ruben Dias is also pushing to be involved as he continues his recovery from an ankle injury suffered earlier this month. He joins fellow defender Josko Gvardiol on the physio’s table.
Injury worry: Rodri
AFP via Getty Images
For Southampton, Flynn Downes is suspended after being sent off against Swansea for violent conduct at the weekend.
So too is Ryan Manning, who is also serving a suspension.
Elsewhere, captain Jack Stephens is a doubt after dropping out of the side to face Bristol City midweek.
Man City vs Southampton prediction
Man City’s performances in the FA Cup have carried an air of inevitability in recent seasons, though they are making an odd habit of falling at the final hurdle.
They were beaten in the final by Crystal Palace last season, and Manchester United the season before that, and will be fully intent on reaching the final again this year.
Southampton will prove a tricky opponent, though, having lost only one of their last 22 matches. The onus will be on the Saints to pull off another upset, but can they keep this magic cup run going?
We expect the City machine to continue rolling on, though Eckert’s men will give them a scare.
Tonda Eckert
PA
Head to head (h2h) history and results
This will be the first meeting between these two sides since matchday 36 of the 2024/25 Premier League season, when they dragged out a goalless draw at St. Mary’s Stadium.
Man City vs Southampton match odds
Odds via Betfair (subject to change).