All posts tagged: Wall

Abivax Crashes Most On Record After Cancer Cases In Trial Data Spooks Wall Street

Abivax Crashes Most On Record After Cancer Cases In Trial Data Spooks Wall Street

French biotech Abivax suffered its largest intraday decline on record after reporting new data on its lead experimental inflammatory bowel disease drug, which showed cancer cases among patients in the clinical trial. The new data certainly point to regulatory headwinds and raise the risk profile for approval. Abivax’s ABTECT maintenance data showed strong efficacy readout, with both once-daily obefazimod doses meeting the primary endpoint at week 44. Clinical remission rates were 50.8% for the 25 mg dose and 51.3% for the 50 mg dose, versus 10.4% for placebo, implying placebo-adjusted remission rates of about 39% to 40% and highly statistically significant results. The problem for the stock was not efficacy, but safety optics… Goldman analyst Esah Hayat pointed out that the market was focused not on efficacy but on cancer cases among patients taking the higher doses of obefazimod: ABTECT maintenance trial out yday (press release) – “at week 44, both the 25 mg and 50 mg once-daily obefazimod doses met the primary endpoint, demonstrating placebo-adjusted clinical remission rates of ∆39.3% and ∆40.3%, respectively (25 …

Every World Cup 2026 fixture at your fingertips: Download your exclusive wall chart for free!

Every World Cup 2026 fixture at your fingertips: Download your exclusive wall chart for free!

World Cup 2026 is here – bringing with it that all-too-familiar heady mix of excitement, optimism and nerves. Fittingly, this summer’s tournament in Canada, Mexico and the United States will be ‘Supersize’. Following the expansion from 32 teams, 48 nations will go for glory at the festival of football in North America, which is set to serve up 104 matches across 16 host cities over 39 days. Keeping track of the biggest World Cup ever will be no mean feat – particularly with games played across four different time zones and many kicking off through the night for UK viewers – but never fear, Radio Times has got you covered. Every fixture will be at your fingertips with our World Cup 2026 wall chart, ensuring that, whatever your allegiances, you don’t miss the moments that matter. The tournament kicks off on Thursday 11 June – with Scotland joining the party in the early hours of Sunday 14 June and England starting their trophy chase on Wednesday 17 June – and runs until the final on …

Instant View: Anthropic IPO filing ratifies Wall Street’s AI obsession

Instant View: Anthropic IPO filing ratifies Wall Street’s AI obsession

NEW YORK, June 1 : AI giant Anthropic said on Monday it has confidentially filed for a U.S. initial public offering, teeing up a watershed moment for Wall Street’s AI frenzy. Tech stocks continue to lead the Nasdaq Composite and S&P 500 in a record-breaking market rally, while Elon Musk’s SpaceX is set to price its IPO this month and Anthropic rival OpenAI, led by Sam Altman, is waiting on deck. MARKET REACTION: U.S. stocks were mixed on Monday afternoon, with the Nasdaq up 0.3 per cent, the S&P 500 up 0.1 per cent and the Dow industrials off 0.3 per cent. Salesforce rose 10 per cent on Monday, following a report that its stake in Anthropic is valued at $5 billion. COMMENTS: MATT KENNEDY, SENIOR STRATEGIST AT RENAISSANCE CAPITAL, NEW YORK:”It’s true that many private tech unicorns have sat on the sidelines waiting for an IPO market that would grant them their desired valuations. That is not the case with Anthropic and other “elite” AI developers.” “Virtually any private round Anthropic raised would have …

Wall Street follows world stocks higher, crude prices ease on potential US-Iran truce extension

Wall Street follows world stocks higher, crude prices ease on potential US-Iran truce extension

NEW YORK, May 29 : U.S. stocks followed world shares higher and crude prices retreated on Friday as investors neared the end of a holiday-shortened week with renewed hopes of progress toward a peaceful resolution to the Iran war. A narrow, tech-led rally lifted all three major U.S. stock indexes to modest gains, and Treasury yields dipped as markets prepared to turn the page on a week and month marked by a tug-of-war between fears that air strikes could shatter a fragile truce and signs that Washington and Tehran are moving closer to the negotiating table. The S&P 500 is poised to notch its ninth straight weekly gain, its longest winning streak since December 2023. All three indexes are set to register monthly advances. Even so, the indexes had pared from session highs as the closing bell drew near. “This administration watches the markets and they like to do big things when the markets are closed to control the messaging before the market has a chance to react,” said Ross Mayfield, investment strategy analyst at …

EU’s big 6 pitch a rival to Wall Street – POLITICO

EU’s big 6 pitch a rival to Wall Street – POLITICO

Back-to-back crises have limited the power of the public purse, so policymakers are hoping professional financiers and savers can do the heavy lifting by putting their money to work in the right places. EU citizens alone have €11 trillion of cash savings sitting in their bank accounts. But vying interests from within the industry and national governments, such as Ireland and Luxembourg, threaten to derail negotiations. That’s convinced the E6 group to agree on the fundamentals among themselves to speed the process along, triggering fears of a two-speed Europe in which some countries are left behind. “I don’t think a separate structure is feasible, because it would conflict with the prevailing perception in all member states today that fragmentation must stop,” Cyprus’ Finance Minister Makis Keravnos, who currently chairs Ecofin meetings, told POLITICO. Devil in the detail The broad strokes of the deal paper over internal divisions within the E6. While all six governments agree on upgrading the EU’s securities regulator into a supercop for the bloc, they disagree on how fast the process should …

How two millennial AI trainers turned Wall Street’s layoff panic into a gold mine

How two millennial AI trainers turned Wall Street’s layoff panic into a gold mine

Felipe Sinisterra and Dave Wang cash big checks, telling Wall Street bankers what’s missing from their AI plans. On a March afternoon, the two highly sought-after trainers in finance addressed employees of a venture capital fund in New York. Wang, 31, showed how Gemini, the AI model developed by Alphabet Inc.’s Google, could be used to analyze founders’ pitch videos. He demonstrated how a web application incorporating behavioral analysis methods used by the FBI could help compare a transcript with visual cues such as body language and facial expressions to spot potential red flags. Sinisterra, 30, then walked the class through how to scan transcripts from earnings calls with OpenAI’s ChatGPT and Anthropic’s Claude to find the most market-moving statements. The machine ran sentiment analysis and translated management’s spoken remarks into numerical spreadsheet inputs to forecast future financials. Participants could see how AI could help streamline some of the most labor-intensive parts of their jobs. The bill for the day? $25,000. And they are backlogged for two months. “What is happening now is that people …

Neighbour leaves residents fuming after erecting 7ft-high ‘Berlin Wall’ boundary | UK | News

Neighbour leaves residents fuming after erecting 7ft-high ‘Berlin Wall’ boundary | UK | News

The vast boundary has been compared to the Berlin Wall by neighbours (Image: BNPS) A homeowner has enraged residents of an affluent neighbourhood after replacing a boundary fence with a vast concrete structure that “looks like the Berlin Wall”. Ken Lynch has had the 75ft-long grey wall constructed along the side of his detached home on Sandbanks Road in the sought-after Lilliput area of Poole, Dorset. The area, alongside its neighbour Sandbanks, are among the most expensive and exclusive seaside areas in the whole country, with average house prices starting at £700,000. The imposing structure stands over 7ft tall and has been branded an eyesore by locals, with some likening it to something straight out of the Soviet Union era. Before its transformation, the home was a charming bungalow with an attractive front garden and modest brick wall that allowed passers-by to enjoy its vibrant herbaceous borders. The previous owner secured planning permission to convert the bungalow into a two-storey house with a sizeable rear extension. The property is now valued at £1m. The house …

Why Your Cofounder Relationship Keeps Hitting the Same Wall

Why Your Cofounder Relationship Keeps Hitting the Same Wall

Two founders I know built a multimillion-dollar agency together. From the outside, it looked like a success story. Inside, one was waking up every morning to a backlog of Slack messages from the other, who started each day trying to contain small fires before his partner even rolled out of bed. Their disagreements weren’t about strategy. They were caught in something more frustrating and harder to name. The most persistent conflicts I see between business partners as a cofounder coach might appear to be focused on operational disagreements about things like equity or product direction. But beneath these superficial topics, their emotional drivers are the same interpersonal dynamics that people bring into every close relationship. Attachment theory offers a useful frame here. Developed by psychologist John Bowlby (1969) and expanded by Mary Ainsworth (1978), the basic idea is that humans are wired for connection, and when that connection feels threatened, we respond in predictable ways. Those responses don’t pause because you’re in a business context. Cofounder relationships are attachment-based relationships. The sustained pressure of building …

Imax Takeover Wall Street Speculates Who May Bid

Imax Takeover Wall Street Speculates Who May Bid

As Imax appears up for sale with early-stage talks with possible suitors, financial analysts have lost no time speculating on who may be a likely buyer. And Wall Street’s list, right now, is long. It stretches from traditional exhibitors (possibly), to private equity firms (could be circling) and tech giants (it would be a rounding error for them) along with a couple major entertainment conglomerates. David Joyce, at Seaport Research Partners, argued Imax is performing well as a standalone large format cinema company. But if the company is for sale, Joyce in a May 22 note pointed to Cinemark or AMC Theatres as logical acquirers, and added “we truly hope it is going to be an all-cash deal for investors since most potential strategic investors would have conflicts of interest that could hinder the trajectory of the business.” Long term Imax investors are no strangers to possible sales talk around the film technologies company as the Toronto-based company, led by CEO Richard Gelfond since 1994, over the years has sounded out the market for a …

SpaceX IPO filing brings Musk’s interplanetary ambitions to Wall Street

SpaceX IPO filing brings Musk’s interplanetary ambitions to Wall Street

May 20 : As Elon Musk’s SpaceX races toward what could be the largest IPO in history, its filing delivers a rare mix of hard financial data and bold ambitions of exploring the frontiers of space. The filing’s references to lunar missions and Mars settlement echo the popular space-age futuristic themes of “The Martian” and “Interstellar,” while grounding those ambitions in the more familiar language of commercial space development. The company identified asteroid mining, in-orbit manufacturing and energy production on the moon and Mars as potential future opportunities, even though these ventures appear nowhere near feasibility. The language in the filing at times veered from conventional corporate disclosure to warnings of existential peril. “We do not want humans to have the same fate as dinosaurs,” the company said, as it made a case for interplanetary travel. The part-balance-sheet, part-science-fiction nature of the paperwork is just one of several signs that show how unprecedented SpaceX’s IPO truly is, in terms of size, ambition and business model. It is also consistent with Musk’s public persona. The billionaire …